Human resources are competitive advantage and most important capital of each organization and undoubtedly human resource development is one of the key processes of human resource management. This research has been done in a research and development center of industrial product which human resource and employee knowledge development play an important role in success of its strategy and mission. Main purpose of this paper is formulating human resource development strategy with employee knowledge development approach. At first, current condition of effective domains in human resource development  have been surveyed and analyzed and then gap of employee knowledge have been identified and main causes of  existence of gap than has considered in suitable strategy selection have been explored. Finally, according to fundamental organization strategy and human resource strategy, human resource development strategies have been formulated. This research is an applied and developmental one and in data compilation wise could be categorized as descriptive-survey.